Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant Non-Small Cell Lung Cancer.

doi:10.1158/2159-8290.CD-24-0421

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Article

Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant Non-Small Cell Lung Cancer.

Cancer discovery - 1 Nov 2024

Araujo Haniel A, Pechuan-Jorge Ximo, Zhou Teng, Do Minh Truong, Hu Xin, Rojas Alvarez Frank R, Salvatierra Maria E, Ibarguen Heladio P, Lee Richard, Raghulan Rashi, Shah Harshit, Moreno Ayala Mariela A, Chen Kevin, Tovbis Shifrin Nataliya, Wu Shuhong, Solis Soto Luisa M, Negrao Marcelo V, Gibbons Don L, Hong David S, Roth Jack A, Heymach John V, Zhang Jianjun, Jiang Jingjing, Singh Mallika, Smith Jacqueline A M, Quintana Elsa, Skoulidis Ferdinandos

Abstract excerpt

Resistance to inactive state-selective RASG12C inhibitors frequently entails accumulation of RASGTP, rendering effective inhibition of active RAS potentially desirable. Here, we evaluated the antitumor activity of the RAS(ON) multiselective tricomplex inhibitor RMC-7977 and dissected mechanisms of response and tolerance in KRASG12C-mutant non-small cell lung cancer (NSCLC). Broad-spectrum reversible RASGTP...

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PMID: 38975897
DOI: 10.1158/2159-8290.CD-24-0421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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