Analysis of Global Collection of Group A Streptococcus Genomes Reveals that the Majority Encode a Trio of M and M-Like Proteins

Abstract excerpt

While the GAS M protein has been the leading vaccine target for decades, the bacteria encode many other virulence factors of interest for vaccine development. In this work, we show that emm -like genes are encoded in a remarkable majority of GAS genomes and expressed at a level similar to that for the emm gene. In collaboration with the U.S. Centers for Disease Control, we developed molecular definitions of the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Neonatal and Maternal Infections
• Share to Plant Pathogenic Bacteria Studies
• Share to Streptococcal Infections and Treatments