Article
Conditional knockout of kisspeptin signaling in brown adipose tissue increases metabolic rate and body temperature and lowers body weight.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2020
Tolson Kristen P, Marooki Nuha, De Bond Julie-Ann P, Walenta Evelyn, Stephens Shannon B Z, Liaw Reanna B, Savur Rishi, Wolfe Andrew, Oh Da Young, Smith Jeremy T, Kauffman Alexander S
Abstract excerpt
The peptide kisspeptin and its receptor, Kiss1r, act centrally to stimulate reproduction. Evidence indicates that kisspeptin signaling is also important for body weight (BW) and metabolism. We recently reported that Kiss1r KO mice develop obesity, along with reduced metabolism and energy expenditure, independent of estradiol levels. Outside the brain, Kiss1r is expressed in several metabolic tissues, including...
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