Article
Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes.
PloS one - 1 Jan 2014
Boyer-Di Ponio Julie, El-Ayoubi Fida, Glacial Fabienne, Ganeshamoorthy Kayathiri, Driancourt Catherine, Godet Maeva, Perrière Nicolas, Guillevic Oriane, Couraud Pierre Olivier, Uzan Georges
Abstract excerpt
OBJECTIVE: The vascular system is adapted to specific functions in different tissues and organs. Vascular endothelial cells are important elements of this adaptation, leading to the concept of 'specialized endothelial cells'. The phenotype of these cells is highly dependent on their specific microenvironment and when isolated and cultured, they lose their specific features after few passages, making models using...
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