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Article

Kinetic Variability in Seeded Formation of ALS-Linked SOD1 Fibrils Across Multiple Generations.

ACS chemical neuroscience - 5 Feb 2020

Baumer Katelyn M, Koone Jordan C, Shaw Bryan F

Abstract excerpt

The unseeded aggregation of superoxide dismutase-1 (SOD1) into amyloid-like fibrils occurs stochastically in vitro and in vivo, that is, isolated populations of SOD1 proteins (within microplate wells or living cells) self-assemble into amyloid at rates that span a probability distribution. This stochasticity has been attributed to variable degrees of monomer depletion by competing pathways of amorphous and...

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PMID: 31895541
DOI: 10.1021/acschemneuro.9b00464

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