Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular and Computational Insights of Novel Mutations in Aminoglycoside-Modifying Genes of P. aeruginosa.

Molecular biotechnology - 1 May 2026

Jalil Huma, Shams Khadija, Ullah Asad, Khan Ibrar, Ahmad Sajjad, Saleem Ayesha, Khan Kalsoom, Salim Muhammad, Abideen Syed Ainul, Aljasir Mohammad Abdullah, Irfan Muhammad

Abstract excerpt

The production of aminoglycoside-modifying genes by P. aeruginosa is one of the key mechanisms by which resistance to aminoglycoside antibiotics is developed. The aim of the present work was to examine the prevalence of aac(6)-Ib, aac(6)-IIa, and aac(3)-IIa aminoglycoside-modifying genes in clinical samples. A total of 500 clinical samples were collected from Khyber Teaching Hospital (KTH), and showed a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminoglycosides
Share to Anti-Bacterial Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bacterial Proteins

Share to Drug Resistance, Bacterial

Share to Microbial Sensitivity Tests

Share to Molecular Docking Simulation

Share to Molecular Dynamics Simulation

Share to Pseudomonas aeruginosa

Source

Identifiers

PMID: 40900295
DOI: 10.1007/s12033-025-01508-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular and Computational Insights of Novel Mutations in Aminoglycoside-Modifying Genes of P. aeruginosa.PMID 40900295Read ↗

The predictive potential of different molecular markers linked to amikacin susceptibility phenotypes in Pseudomonas aeruginosa.Semantic proximity Read ↗

Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogensSemantic proximity Read ↗

Accessory genes define species-specific pathways to antibiotic resistanceSemantic proximity Read ↗

Role of Aminoglycoside‐Modifying Enzymes (AMEs) in Resistance to Aminoglycosides among Clinical Isolates of Pseudomonas aeruginosa in the North of IranSemantic proximity Read ↗

Evaluation of Aminoglycoside and Carbapenem Resistance in a Collection of Drug-Resistant Pseudomonas aeruginosa Clinical IsolatesSemantic proximity Read ↗

Pathogenicity of nosocomial Pseudomonas aeruginosa analyzed by pan-genomicsSemantic proximity Read ↗

Keeping up with the pathogens: Improved antimicrobial resistance detection and prediction from<i>Pseudomonas</i>aeruginosa genomesSemantic proximity Read ↗

Pseudomonas aeruginosa ceftolozane-tazobactam resistance development requires multiple mutations leading to overexpression and structural modification of AmpC.Semantic proximity Read ↗

Relationship between antimicrobial resistance and aminoglycoside-modifying enzyme gene expressions in Acinetobacter baumannii.Semantic proximity Read ↗

Imipenem resistance associated with amino acid alterations of the OprD porin in Pseudomonas aeruginosa clinical isolatesSemantic proximity Read ↗

Genome-wide analyses reveal antibiotic resistance genes and mechanisms in pathogenic Pseudomonas bacteriaSemantic proximity Read ↗

Keeping up with the pathogens: improved antimicrobial resistance detection and prediction from Pseudomonas aeruginosa genomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.