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Article

The multidrug resistance transporter P-glycoprotein confers resistance to ferroptosis inducers

1 Jan 2023

Abstract excerpt

Aim: Ferroptosis is a non-apoptotic form of cell death caused by lethal lipid peroxidation. Several small molecule ferroptosis inducers (FINs) have been reported, yet little information is available regarding their interaction with the ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp, ABCB1) and ABCG2. We thus sought to characterize the interactions of FINs with P-gp and ABCG2, which may provide...

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PMID: 37840856
DOI: 10.20517/cdr.2023.29

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