Article
Capture of complete ciliate chromosomes in single sequencing reads reveals widespread chromosome isoforms.
BMC genomics - 30 Dec 2019
Lindblad Kelsi A, Pathmanathan Jananan S, Moreira Sandrine, Bracht John R, Sebra Robert P, Hutton Elizabeth R, Landweber Laura F
Abstract excerpt
BACKGROUND: Whole-genome shotgun sequencing, which stitches together millions of short sequencing reads into a single genome, ushered in the era of modern genomics and led to a rapid expansion of the number of genome sequences available. Nevertheless, assembly of short reads remains difficult, resulting in fragmented genome sequences. Ultimately, only a sequencing technology capable of capturing complete...
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