The Oxytricha trifallax macronuclear genome: a complex eukaryotic genome with 16,000 tiny chromosomes.

doi:10.1371/journal.pbio.1001473

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Article

The Oxytricha trifallax macronuclear genome: a complex eukaryotic genome with 16,000 tiny chromosomes.

PLoS biology - 1 Jan 2013

Swart Estienne C, Bracht John R, Magrini Vincent, Minx Patrick, Chen Xiao, Zhou Yi, Khurana Jaspreet S, Goldman Aaron D, Nowacki Mariusz, Schotanus Klaas, Jung Seolkyoung, Fulton Robert S, Ly Amy, McGrath Sean, Haub Kevin, Wiggins Jessica L, Storton Donna, Matese John C, Parsons Lance, Chang Wei-Jen, Bowen Michael S, Stover Nicholas A, Jones Thomas A, Eddy Sean R, Herrick Glenn A, Doak Thomas G, Wilson Richard K, Mardis Elaine R, Landweber Laura F

Abstract excerpt

The macronuclear genome of the ciliate Oxytricha trifallax displays an extreme and unique eukaryotic genome architecture with extensive genomic variation. During sexual genome development, the expressed, somatic macronuclear genome is whittled down to the genic portion of a small fraction (∼5%) of its precursor "silent" germline micronuclear genome by a process of "unscrambling" and fragmentation. The tiny...

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PMID: 23382650
DOI: 10.1371/journal.pbio.1001473
PMCID: PMC3558436

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