Article
TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
Autophagy - 1 Oct 2020
Chang Kai, Kang Ping, Liu Ying, Huang Kerui, Miao Ting, Sagona Antonia P, Nezis Ioannis P, Bodmer Rolf, Ocorr Karen, Bai Hua
Abstract excerpt
Age-related impairment of macroautophagy/autophagy and loss of cardiac tissue homeostasis contribute significantly to cardiovascular diseases later in life. MTOR (mechanistic target of rapamycin kinase) signaling is the most well-known regulator of autophagy, cellular homeostasis, and longevity. The MTOR signaling consists of two structurally and functionally distinct multiprotein complexes, MTORC1 and MTORC2....
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