Role of Autophagy in Aging

doi:10.1097/fjc.0b013e31824cc31c

Article

Role of Autophagy in Aging

11 Feb 2012

Abstract excerpt

Constitutive autophagy is important for the control of the quality of proteins and organelles to maintain cell function. Damaged proteins and organelles accumulate in aged organs. The level of autophagic activity decreases with aging. Autophagic activity is regulated by many factors, such as the insulin receptor-signaling pathway, the TOR pathway, Sirt1, and caloric restriction. Autophagy-related genes are known...

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