High degree of polyclonality hinders somatic mutation calling in lung brush samples of COPD cases and controls.

doi:10.1038/s41598-019-56618-1

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Article

High degree of polyclonality hinders somatic mutation calling in lung brush samples of COPD cases and controls.

Scientific reports - 27 Dec 2019

Thun Gian-Andri, Derdak Sophia, Castro-Giner Francesc, Apunte-Ramos Katherine, Águeda Lidia, Wjst Matthias, Boland Anne, Deleuze Jean-François, Kolsum Umme, Heiss-Neumann Marion S, Nowinski Adam, Gorecka Dorota, Hohlfeld Jens M, Welte Tobias, Brightling Christopher E, Parr David G, Prasse Antje, Müller-Quernheim Joachim, Greulich Timm, Stendardo Mariarita, Boschetto Piera, Barta Imre, Döme Balázs, Gut Marta, Singh Dave, Ziegler-Heitbrock Loems, Gut Ivo G

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) is induced by cigarette smoking and characterized by inflammation of airway tissue. Since smokers with COPD have a higher risk of developing lung cancer than those without, we hypothesized that they carry more mutations in affected tissue. We called somatic mutations in airway brush samples from medium-coverage whole genome sequencing data from healthy never and...

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PMID: 31882973
DOI: 10.1038/s41598-019-56618-1
PMCID: PMC6934450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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