Article
In vitro evolution of allergy vaccine candidates, with maintained structure, but reduced B cell and T cell activation capacity.
PloS one - 1 Jan 2011
Nilsson Ola B, Adedoyin Justus, Rhyner Claudio, Neimert-Andersson Theresa, Grundström Jeanette, Berndt Kurt D, Crameri Reto, Grönlund Hans
Abstract excerpt
Allergy and asthma to cat (Felis domesticus) affects about 10% of the population in affluent countries. Immediate allergic symptoms are primarily mediated via IgE antibodies binding to B cell epitopes, whereas late phase inflammatory reactions are mediated via activated T cell recognition of allergen-specific T cell epitopes. Allergen-specific immunotherapy relieves symptoms and is the only treatment inducing a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.