Article
Dimerization of small integral membrane protein 1 promotes cell surface presentation of the Vel blood group epitope.
FEBS letters - 1 Apr 2020
Kelley Liam P, Nylander Anja, Arnaud Lionel, Schmoker Anna M, St Clair Riley M, Gleason Lindsey A, Souza Jessica M, Storry Jill R, Olsson Martin L, Ballif Bryan A
Abstract excerpt
The Vel blood group antigen is carried on the short extracellular segment of the 78-amino-acid-long, type II transmembrane protein SMIM1 of unknown function. Here, using biochemical analysis and flow cytometry of cells expressing wild-type and mutant alleles of SMIM1, we demonstrate that dimerization of SMIM1 promotes cell surface display of the Vel epitope. We show that SMIM1 dimerization is mediated both by an...
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