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Article

Molecular identification of Vel-negative blood donors in a population from southern Brazil.

Vox sanguinis - 1 Mar 2026

Siegel D, Schörner E J, Schörner M A, Grisard H, Barazzetti F H, Kupek E, Bazzo M L

Abstract excerpt

BACKGROUND AND OBJECTIVES: The Vel antigen is clinically significant and its alloantibody is involved in haemolytic transfusion reactions. This antigen has a high prevalence in the population. The Vel-negative phenotype is the result of a homozygous deletion in the SMIM1 gene (c.64_80del) and hinders the expression of the SMIM1 protein. MATERIALS AND METHODS: A total of 17,472 blood donor samples from the Center...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41692403
DOI: 10.1111/vox.70187

Genes

SMIM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

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Molecular identification of Vel-negative blood donors in a population from southern Brazil.PMID 41692403Read ↗

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Screening for the SMIM1*64_80 del Allele in blood donors in a population from Southern Brazil.Semantic proximity Read ↗

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SMIM1 underlies the Vel blood group and influences red blood cell traits.Semantic proximity Read ↗

Impact of genetic variation in the SMIM1 gene on Vel expression levels.Semantic proximity Read ↗

The c.64_80del SMIM1 allele is segregating in the Hutterite population.Semantic proximity Read ↗

Beyond the rare blood group Vel, uncovering the functions of SMIM1 in blood and in other organsSemantic proximity Read ↗

SMIM1 variants rs1175550 and rs143702418 independently modulate Vel blood group antigen expression.Semantic proximity Read ↗

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