Article
SMIM1 polymorphisms in a donor population from southeast Brazil and their correlation with VEL expression.
Blood transfusion = Trasfusione del sangue - 1 Jan 2019
Arnoni Carine Prisco, De Paula Vendrame Tatiane A, Muniz Janaína Guilhem, Gazito Diana, De Medeiros Person Rosangela Duarte, Pereira Cortez Afonso J, Latini Flavia R M, Castilho Lilian
Abstract excerpt
BACKGROUND: Vel is a high frequency blood group antigen and its alloantibody is involved in haemolytic transfusion reactions. After elucidation of the molecular basis of the Vel-negative phenotype defined by a 17-base pair deletion in SMIM1, genotyping has been the technique of choice to identify the Vel-negative phenotype, and molecular investigations have contributed to explain Vel expression variability. The...
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