Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ChaC1 upregulation reflects poor prognosis in a variety of cancers: analysis of the major missense SNPs of ChaC1 as an aid to refining prognosis.

Gene - 30 Jun 2024

Parande Devraj, Suyal Shradha, Bachhawat Anand K

Abstract excerpt

The ChaC1 enzyme that catalyzes cytosolic glutathione degradation is highly upregulated in several cancers. In a systematic review of gene signature panels for cancer prognosis based on oxidative stress and ferroptosis genes, we observed that ChaC1 was found in panels in a wide variety of different cancers, with the upregulation correlating with poor prognosis. Since SNPs can have an impact on functionality and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neoplasms
Share to Oxidative Stress
Share to Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Up-Regulation

Source

Identifiers

PMID: 38499213
DOI: 10.1016/j.gene.2024.148386

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ChaC1 upregulation reflects poor prognosis in a variety of cancers: analysis of the major missense SNPs of ChaC1 as an aid to refining prognosis.PMID 38499213Read ↗

CHAC1: a master regulator of oxidative stress and ferroptosis in human diseases and cancersSemantic proximity Read ↗

Ferroptosis‐related gene CHAC1 is a valid indicator for the poor prognosis of kidney renal clear cell carcinomaSemantic proximity Read ↗

Upregulation of CHAC1 promotes bladder inflammation and predicts adverse prognosis in Bladder Urothelial CarcinomaSemantic proximity Read ↗

Exploring CISD1 as a multifaceted biomarker in cancer: Implications for diagnosis, prognosis, and immunotherapeutic responseSemantic proximity Read ↗

ABCC2 induces metabolic vulnerability and cellular ferroptosis via enhanced glutathione efflux in gastric cancerSemantic proximity Read ↗

Mutation-Structure-Function Relationship Based Integrated Strategy Reveals the Potential Impact of Deleterious Missense Mutations in Autophagy Related Proteins on Hepatocellular Carcinoma (HCC): A Comprehensive Informatics Approach.Semantic proximity Read ↗

Prediction of deleterious non-synonymous SNPs of human MDC1 gene: an in silico approach.Semantic proximity Read ↗

ABC gene expression profiles have clinical importance and possibly form a new hallmark of cancerSemantic proximity Read ↗

Concurrent Mutations in STK11 and KEAP1 Promote Ferroptosis Protection and SCD1 Dependence in Lung Cancer.Semantic proximity Read ↗

Cancer-associated isocitrate dehydrogenase mutations.Semantic proximity Read ↗

Structural and Functional Analyses of Human ChaC2 in Glutathione Metabolism.Semantic proximity Read ↗

Potentially functional variants of PARK7 and DDR2 in ferroptosis-related genes predict survival of non-small cell lung cancer patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.