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Sequence type-258 carbapenem-resistant Klebsiella pneumoniae isolates in which ceftazidime-avibactam resistance emerged are not hypermutators.

Diagnostic microbiology and infectious disease - 1 Mar 2020

Squires Kevin M, Nguyen M Hong, Shields Ryan K, Clancy Cornelius J

Abstract excerpt

Ceftazidime-avibactam resistance among carbapenem-resistant Klebsiella pneumoniae at our hospital has emerged in sequence type (ST)-258, clade II isolates. We investigated hypermutability of ST258, clade II (n = 6) and clade I K. pneumoniae (n = 8) using a standard rifampin assay. Mutational frequencies were ≤10-7.1, indicating that isolates were not hypermutators. Mutational frequencies did not differ between...

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PMID: 31864758
DOI: 10.1016/j.diagmicrobio.2019.114954

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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