Article
Doripenem MICs and ompK36 porin genotypes of sequence type 258, KPC-producing Klebsiella pneumoniae may predict responses to carbapenem-colistin combination therapy among patients with bacteremia.
Antimicrobial agents and chemotherapy - 1 Mar 2015
Shields Ryan K, Nguyen M Hong, Potoski Brian A, Press Ellen G, Chen Liang, Kreiswirth Barry N, Clarke Lloyd G, Eschenauer Gregory A, Clancy Cornelius J
Abstract excerpt
Treatment failures of a carbapenem-colistin regimen among patients with bacteremia due to sequence type 258 (ST258), KPC-2-producing Klebsiella pneumoniae were significantly more likely if both agents were inactive in vitro, as defined by a colistin MIC of >2 μg/ml and the presence of either a ma...
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