Article
Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2014
Deleo Frank R, Chen Liang, Porcella Stephen F, Martens Craig A, Kobayashi Scott D, Porter Adeline R, Chavda Kalyan D, Jacobs Michael R, Mathema Barun, Olsen Randall J, Bonomo Robert A, Musser James M, Kreiswirth Barry N
Abstract excerpt
Infections caused by drug-resistant bacteria are a major problem worldwide. Carbapenem-resistant Klebsiella pneumoniae, most notably isolates classified as multilocus sequence type (ST) 258, have emerged as an important cause of hospital deaths. ST258 isolates are predominantly multidrug resistant, and therefore infections caused by them are difficult to treat. It is not known why the ST258 lineage is the most...
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