Article
Colistin Resistance Caused by Inactivation of the MgrB Regulator Is Not Associated with Decreased Virulence of Sequence Type 258 KPC Carbapenemase-Producing Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy - 1 Apr 2016
Arena Fabio, Henrici De Angelis Lucia, Cannatelli Antonio, Di Pilato Vincenzo, Amorese Marina, D'Andrea Marco Maria, Giani Tommaso, Rossolini Gian Maria
Abstract excerpt
Using aGalleria mellonellaanimal model, we compared the virulence of two sequence type 258 (ST258) KPC-producingKlebsiella pneumoniaestrains, which were representative of the two clades of this clonal lineage, with that of isogenic colistin-resistantmgrBmutants. With both strains, themgrBmutants did not exhibit modification in virulence. In theG. mellonellamodel, the clade 1 strain (capsular typecps-1[wzi29,...
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