Article
A peep into mitochondrial disorder: multifaceted from mitochondrial DNA mutations to nuclear gene modulation.
Protein & cell - 1 Dec 2015
Chen Chao, Chen Ye, Guan Min-Xin
Abstract excerpt
Mitochondrial genome is responsible for multiple human diseases in a maternal inherited pattern, yet phenotypes of patients in a same pedigree frequently vary largely. Genes involving in epigenetic modification, RNA processing, and other biological pathways, rather than "threshold effect" and environmental factors, provide more specific explanation to the aberrant phenotype. Thus, the double hit theory, mutations...
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