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Acetylation of cedrelone increases its cytotoxic activity and reverts the malignant phenotype of breast cancer cells in 3D culture.

Chemico-biological interactions - 25 Jan 2020

Becceneri Amanda Blanque, Fuzer Angelina Maria, Popolin Cecília Patrícia, Cazal Cristiane de Melo, Domingues Vanessa de Cássia, Fernandes João Batista, Vieira Paulo Cezar, Cominetti Marcia Regina

Abstract excerpt

Cedrelone is a limonoid isolated from the plant Trichilia catigua (Meliaceae). Previous studies have demonstrated that cedrelone (1) has several damaging effects on triple negative breast tumor (TNBC) cell line MDA-MB-231. In this work we investigated two new derivatives of cedrelone, the acetate (1a) and the mesylate (1b), to examine whether their effects are improved in comparison to the lead molecule....

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Identifiers

PMID: 31857088
DOI: 10.1016/j.cbi.2019.108920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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