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Article

Metochalcone induces senescence-associated secretory phenotype via JAK2/STAT3 pathway in breast cancer.

Oncology research - 1 Jan 2024

Zhou Jianbo, Wan Feng, Xiao Bin, Li Xin, Peng Cheng, Peng F U

Abstract excerpt

Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men, respectively, worldwide. Although the antitumor activity of chalcones has been extensively studied, the molecular mechanisms of isoliquiritigenin analog 2', 4', 4-trihydroxychalcone (metochalcone; TEC) against carcinomas remain less well understood. In this study, we found that TEC inhibited cell...

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Identifiers

PMID: 38686052
DOI: 10.32604/or.2023.044775
PMCID: PMC11055985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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