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Article

FOXP3 pathogenic variants cause male infertility through affecting the proliferation and apoptosis of human spermatogonial stem cells.

Aging - 19 Dec 2019

Qiu Qianqian, Yu Xing, Yao Chencheng, Hao Yujun, Fan Liqing, Li Chunyi, Xu Peng, An Geng, Li Zheng, He Zuping

Abstract excerpt

Genetic causes of male infertility that is associated with aging are largely unknown. This study was designed to identify novel pathogenic variants of FOXP3 gene causing azoospermia. One homozygous (c.155 G > T) pathogenic variant of FOXP3 was identified in nine non-obstructive azoospermia patients, and one heterozygous (c.691 C > A) of FOXP3 was found in one non-obstructive azoospermia patient. Pedigrees studies...

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Identifiers

PMID: 31855573
DOI: 10.18632/aging.102589
PMCID: PMC6949051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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