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Article

Y chromosome haplogroups based genome-wide association study pinpoints revelation for interactions on non-obstructive azoospermia.

Scientific reports - 15 Sept 2016

Lu Chuncheng, Wen Yang, Hu Weiyue, Lu Feng, Qin Yufeng, Wang Ying, Li Shilin, Yang Shuping, Lin Yuan, Wang Cheng, Jin Li, Shen Hongbing, Sha Jiahao, Wang Xinru, Hu Zhibin, Xia Yankai

Abstract excerpt

The Y chromosome has high genetic variability with low rates of parallel and back mutations, which make up the most informative haplotyping system. To examine whether Y chromosome haplogroups (Y-hgs) could modify the effects of autosomal variants on non-obstructive azoospermia (NOA), based on our previous genome-wide association study (GWAS), we conducted a genetic interaction analysis in GWAS subjects. Logistic...

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PMID: 27628680
DOI: 10.1038/srep33363
PMCID: PMC5024297

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