Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.

doi:10.1038/s41467-019-13650-z

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.

Nature communications - 18 Dec 2019

Marg Andreas, Escobar Helena, Karaiskos Nikos, Grunwald Stefanie A, Metzler Eric, Kieshauer Janine, Sauer Sascha, Pasemann Diana, Malfatti Edoardo, Mompoint Dominique, Quijano-Roy Susanna, Boltengagen Anastasiya, Schneider Joanna, Schülke Markus, Kunz Séverine, Carlier Robert, Birchmeier Carmen, Amthor Helge, Spuler Andreas, Kocks Christine, Rajewsky Nikolaus, Spuler Simone

Abstract excerpt

Skeletal muscle stem cells, called satellite cells and defined by the transcription factor PAX7, are responsible for postnatal muscle growth, homeostasis and regeneration. Attempts to utilize the regenerative potential of muscle stem cells for therapeutic purposes so far failed. We previously established the existence of human PAX7-positive cell colonies with high regenerative potential. We now identified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Human Umbilical Vein Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lectins, C-Type

Share to PAX7 Transcription Factor

Share to Primary Cell Culture

Share to Regeneration

Share to Satellite Cells, Skeletal Muscle

Share to Single-Cell Analysis

Share to Transplantation, Heterologous

Source

Open in PubMed Open full text

Identifiers

PMID: 31852888
DOI: 10.1038/s41467-019-13650-z
PMCID: PMC6920394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7.PMID 31852888Read ↗

Human Satellite Cell Transplantation and Regeneration from Diverse Skeletal MusclesSemantic proximity Read ↗

Analysis of human muscle stem cells reveals a differentiation‐resistant progenitor cell population expressing Pax7 capable of self‐renewalSemantic proximity Read ↗

PAX7 Targets, CD54, Integrin α9β1, and SDC2, Allow Isolation of Human ESC/iPSC-Derived Myogenic ProgenitorsSemantic proximity Read ↗

Functionally heterogeneous human satellite cells identified by single cell RNA sequencingSemantic proximity Read ↗

Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitorsSemantic proximity Read ↗

Human and Mouse Skeletal Muscle Stem Cells: Convergent and Divergent Mechanisms of MyogenesisSemantic proximity Read ↗

Mechanisms of cooperative cell-cell interactions in skeletal muscle regenerationSemantic proximity Read ↗

A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populationsSemantic proximity Read ↗

Differentiation of the human PAX7-positive myogenic precursors/satellite cell lineage in vitroSemantic proximity Read ↗

Extraocular muscle stem cells exhibit distinct cellular properties associated with non-muscle molecular signaturesSemantic proximity Read ↗

Notch ligands regulate the muscle stem-like state ex vivo but are not sufficient for retaining regenerative capacitySemantic proximity Read ↗

Single-cell sequencing deconvolutes cellular responses to exercise in human skeletal muscleSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.