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Article

HIV cell fusion assay: phenotypic screening tool for the identification of HIV entry inhibitors via CXCR4.

Journal of biomolecular screening - 1 Jan 2014

Smith Elizabeth B, Ogert Robert A, Pechter David, Villafania Artjohn, Abbondanzo Susan J, Lin Karen, Rivera-Gines Aida, Rebsch-Mastykarz Cheryl, Monsma Frederick J

Abstract excerpt

The health and disease-related biology of the CXCR4 chemokine receptor presents the challenge of finding a small molecule that can bind CXCR4 and block T-cell tropic human immunodeficiency virus type 1 (HIV-1) cell entry, while preserving the ability of CXCR4 to respond to its native ligand, CXCL12. HIV entry into the host cell involves the interaction of the viral envelope glycoprotein gp120 binding to CD4,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23989454
DOI: 10.1177/1087057113500074

Genes

CXCR4
CCR5
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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