Article
Longitudinal RNA-Seq Analysis of the Repeatability of Gene Expression and Splicing in Human Platelets Identifies a Platelet SELP Splice QTL.
Circulation research - 14 Feb 2020
Rondina Matthew T, Voora Deepak, Simon Lukas M, Schwertz Hansjörg, Harper Julie F, Lee Olivia, Bhatlekar Seema C, Li Qing, Eustes Alicia S, Montenont Emilie, Campbell Robert A, Tolley Neal D, Kosaka Yasuhiro, Weyrich Andrew S, Bray Paul F, Rowley Jesse W
Abstract excerpt
RATIONALE: Longitudinal studies are required to distinguish within versus between-individual variation and repeatability of gene expression. They are uniquely positioned to decipher genetic signal from environmental noise, with potential application to gene variant and expression studies. However, longitudinal analyses of gene expression in healthy individuals-especially with regards to alternative splicing-are...
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