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Article

Deducing the Role of Virus Genome-Derived PIWI-Associated RNAs in the Mosquito–Arbovirus Arms Race

28 Nov 2019

Abstract excerpt

The PIWI-associated RNA (piRNA) pathway is known for its role in protection of genome integrity in the germline of Drosophila melanogaster by silencing transposable elements. The piRNAs that target transposons originate in piRNA clusters in transposon-rich regions of the Drosophila genome. In Aedes aegypti and Ae. albopictus mosquitoes, which are among the most important vectors of arthropod-borne viruses...

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PMID: 31850054
DOI: 10.3389/fgene.2019.01114

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