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Article

Arbovirus-Derived piRNAs Exhibit a Ping-Pong Signature in Mosquito Cells

24 Jan 2012

Abstract excerpt

The siRNA pathway is an essential antiviral mechanism in insects. Whether other RNA interference pathways are involved in antiviral defense remains unclear. Here, we report in cells derived from the two main vectors for arboviruses, Aedes albopictus and Aedes aegypti, the production of viral small RNAs that exhibit the hallmarks of ping-pong derived piwi-associated RNAs (piRNAs) after infection with positive or...

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PMID: 22292064
DOI: 10.1371/journal.pone.0030861

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