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PIWIs Go Viral: Arbovirus-Derived piRNAs in Vector Mosquitoes

29 Dec 2016

Abstract excerpt

Vector mosquitoes are responsible for transmission of the majority of arthropod-borne (arbo-) viruses. Virus replication in these vectors needs to be sufficiently high to permit efficient virus transfer to vertebrate hosts. The mosquito immune response therefore is a key determinant for arbovirus transmission. Mosquito antiviral immunity is primarily mediated by the small interfering RNA pathway. Besides this...

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PMID: 28033427
DOI: 10.1371/journal.ppat.1006017

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