Article
Investigation of conformational dynamics of Tyr89Cys mutation in protection of telomeres 1 gene associated with familial melanoma.
Journal of biomolecular structure & dynamics - 1 Jan 2021
Amir Mohd, Ahamad Shahzaib, Mohammad Taj, Jairajpuri Deeba Shamim, Hasan Gulam Mustafa, Dohare Ravins, Islam Asimul, Ahmad Faizan, Hassan Md Imtaiyaz
Abstract excerpt
Protection of telomeres 1 (POT1) is a component of the shelterin complex which is crucial for the regulation of telomere length and maintenance. Many naturally occurring mutations in the POT1 gene have been found to be associated with cardiac angiosarcoma, glioma, familial melanoma, and chronic lymphocytic leukemia. In particular, Y89C is a naturally occurring mutation of POT1, responsible for familial melanoma,...
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