Article

POT1 tumor predisposition: a broader spectrum of associated malignancies and proposal for additional screening program

2024-01-15

Abstract excerpt

<title>Abstract</title> <p>Protection of Telomeres Protein 1 protein is an essential subunit of the shelterin telomere binding complex, regulating telomere length. Some <italic>POT1</italic> gene pathogenic variants lead to telomere elongation and consequently genomic instability, which predisposes to a higher risk of cancer. <italic>POT1</italic> tumour predisposition (POT1-TPD) is inherited in an autosomal domi...

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Literature Corpus work: f4665131-9bd9-555c-b546-cb84758020d5
DOI: 10.21203/rs.3.rs-3763002/v1

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