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Article

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy

2 Sept 2016

Abstract excerpt

The intronic GGGGCC hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) is a prevalent genetic abnormality identified in both frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Smith-Magenis syndrome chromosomal region candidate gene 8 (SMCR8) is a protein with unclear functions. We report that C9ORF72 is a component of a multiprotein complex containing SMCR8,...

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PMID: 27617292
DOI: 10.1126/sciadv.1601167

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A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagyPMID 27617292Read ↗

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