Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ivermectin inhibits HSP27 and potentiates efficacy of oncogene targeting in tumor models

16 Dec 2019

Abstract excerpt

HSP27 is highly expressed in, and supports oncogene addiction of, many cancers. HSP27 phosphorylation is a limiting step for activation of this protein and a target for inhibition, but its highly disordered structure challenges rational structure-guided drug discovery. We performed multistep biochemical, structural, and computational experiments to define a spherical 24-monomer complex composed of 12 HSP27 dimers...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helminth infection and control
Share to Parasites and Host Interactions
Share to Parasitic Diseases Research and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31845908
DOI: 10.1172/jci130819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ivermectin inhibits HSP27 and potentiates efficacy of oncogene targeting in tumor modelsPMID 31845908Read ↗

Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancerSemantic proximity Read ↗

Heat-shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAFSemantic proximity Read ↗

Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis.Semantic proximity Read ↗

Heat shock protein 27 (HSP27): biomarker of disease and therapeutic targetSemantic proximity Read ↗

HSP70 Multi-Functionality in CancerSemantic proximity Read ↗

Diptoindonesin G is a middle domain HSP90 modulator for cancer treatment.Semantic proximity Read ↗

Heat Shock Proteins Promote Cancer: It's a Protection Racket.Semantic proximity Read ↗

A Decade of Clinical Experience with DARPins in Oncology and Virology: A Systematic ReviewSemantic proximity Read ↗

Small-Molecule HSP27 Inhibitor Abolishes Androgen Receptors in Glioblastoma.Semantic proximity Read ↗

Chaperoning the Cancer: The Proteostatic Functions of the Heat Shock Proteins in CancerSemantic proximity Read ↗

High-throughput screens identify HSP90 inhibitors as potent therapeutics that target inter-related growth and survival pathways in advanced prostate cancerSemantic proximity Read ↗

In silico evaluation of human small heat shock protein HSP27: homology modeling, mutation analyses and docking studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.