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Article

Small-Molecule HSP27 Inhibitor Abolishes Androgen Receptors in Glioblastoma.

Journal of medicinal chemistry - 11 Feb 2021

Li Yaxin, Orahoske Cody M, Geldenhuys Werner J, Bhattarai Asmita, Sabbagh Abboud, Bobba Viharika, Salem Fatma M, Zhang Wenjing, Shukla Girish C, Lathia Justin D, Wang Bingcheng, Su Bin

Abstract excerpt

Androgen receptor (AR) contributes to the progression of glioblastoma (GBM), and antiandrogen agents have the potential to be used for the treatment of GBM. However, AR mutation commonly happens in GBM, which makes the antiandrogen agents less effective. Heat shock 27 kDa protein (HSP27) is a well-documented chaperone protein to stabilize ARs. Inhibition of HSP27 results in AR degradation regardless of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33523674
DOI: 10.1021/acs.jmedchem.0c01537
PMCID: PMC8284899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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