A Deleted Deletion Site in a New Vector Strain and Exceptional Genomic Stability of Plaque-Purified Modified Vaccinia Ankara (MVA).

doi:10.1007/s12250-019-00176-3

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Article

A Deleted Deletion Site in a New Vector Strain and Exceptional Genomic Stability of Plaque-Purified Modified Vaccinia Ankara (MVA).

Virologica Sinica - 1 Apr 2020

Jordan Ingo, Horn Deborah, Thiele Kristin, Haag Lars, Fiddeke Katharina, Sandig Volker

Abstract excerpt

Vectored vaccines based on highly attenuated modified vaccinia Ankara (MVA) are reported to be immunogenic, tolerant to pre-existing immunity, and able to accommodate and stably maintain very large transgenes. MVA is usually produced on primary chicken embryo fibroblasts, but production processes based on continuous cell lines emerge as increasingly robust and cost-effective alternatives. An isolate of a hitherto...

Topics

Animals
Cell Line
Ducks
Genetic Vectors
Genomic Instability
Genotype
Point Mutation
Recombination, Genetic
Sequence Deletion
Vaccinia virus
Viral Plaque Assay
Virus Replication

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Identifiers

PMID: 31833037
DOI: 10.1007/s12250-019-00176-3
PMCID: PMC7198643

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