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A Common Live-Attenuated Avian Herpesvirus Vaccine Expresses a Very Potent Oncogene

9 Oct 2019

Abstract excerpt

Marek’s disease virus (MDV) is one of several oncogenic herpesviruses and causes fatal lymphomas in chickens. The current “gold standard” vaccine is the live-attenuated MDV strain CVI988/Rispens (CVI), which is widely used and efficiently prevents tumor formation. Intriguingly, CVI expresses two predominant isoforms of the major MDV oncogene meq : one variant with a regular size of meq ( Smeq ) and one long...

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PMID: 31597721
DOI: 10.1128/msphere.00658-19

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