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CRYAB inhibits migration and invasion of bladder cancer cells through the PI3K/AKT and ERK pathways

23 Oct 2019

Abstract excerpt

BACKGROUND: Bladder cancer is a common malignancy characterized by a high recurrence rate and the development of drug resistance. Frequent mutations and gene expression alterations in the PI3K/AKT and mitogen-activated protein kinase-ERK pathways lead to deregulated cell growth and the acquisition of invasive properties, which facilitates tumour progression and confers resistance to chemotherapy. Therefore,...

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PMID: 31829429
DOI: 10.1093/jjco/hyz172

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