Article
Elevated Choline Kinase α-Mediated Choline Metabolism Supports the Prolonged Survival of TRAF3-Deficient B Lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2020
Gokhale Samantha, Lu Wenyun, Zhu Sining, Liu Yingying, Hart Ronald P, Rabinowitz Joshua D, Xie Ping
Abstract excerpt
Specific deletion of the tumor suppressor TRAF3 from B lymphocytes in mice leads to the prolonged survival of mature B cells and expanded B cell compartments in secondary lymphoid organs. In the current study, we investigated the metabolic basis of TRAF3-mediated regulation of B cell survival by employing metabolomic, lipidomic, and transcriptomic analyses. We compared the polar metabolites, lipids, and metabolic...
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