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Article

SMN complex member Gemin3 self-interacts and has a functional relationship with ALS-linked proteins TDP-43, FUS and Sod1.

Scientific reports - 10 Dec 2019

Cacciottolo Rebecca, Ciantar Joanna, Lanfranco Maia, Borg Rebecca M, Vassallo Neville, Bordonné Rémy, Cauchi Ruben J

Abstract excerpt

The predominant motor neuron disease in infants and adults is spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS), respectively. SMA is caused by insufficient levels of the Survival Motor Neuron (SMN) protein, which operates as part of the multiprotein SMN complex that includes the DEAD-box RNA helicase Gemin3/DDX20/DP103. C9orf72, SOD1, TDP-43 and FUS are ranked as the four major genes causing...

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PMID: 31822699
DOI: 10.1038/s41598-019-53508-4
PMCID: PMC6904755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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