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Mutations in transmembrane proteins: diseases, evolutionary insights, prediction and comparison with globular proteins

3 Jun 2020

Abstract excerpt

Membrane proteins are unique in that they interact with lipid bilayers, making them indispensable for transporting molecules and relaying signals between and across cells. Due to the significance of the protein's functions, mutations often have profound effects on the fitness of the host. This is apparent both from experimental studies, which implicated numerous missense variants in diseases, as well as from...

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PMID: 32672331
DOI: 10.1093/bib/bbaa132

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