Article
Cells with ganglionic differentiation frequently stain for VE1 antibody: a potential pitfall.
Brain tumor pathology - 1 Jan 2020
Tan C L, Lian D W Q, Kuick C H, Chan Y H, Chang K T E
Abstract excerpt
Mitogen-activated protein kinase (MAPK) pathway plays a major role in pediatric low-grade gliomas (pLGGs). Immunohistochemistry with mutant-specific antibody, VE1, has appeared to be the most affordable and rapidly deployable method to identify tumors with aberrant MAPK signaling pathway, by highlighting tumor with BRAFV600E mutation. Nonetheless, positive staining cases but not associated with BRAFV600E mutation...
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