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Article

A novel role for Cdk1/cyclin B in regulating B-raf activation at mitosis.

Molecular biology of the cell - 1 Jul 2008

Borysov Sergiy I, Guadagno Thomas M

Abstract excerpt

MAPK activity is important during mitosis for spindle assembly and maintenance of the spindle checkpoint arrest. We previously identified B-Raf as a critical activator of the MAPK cascade during mitosis in Xenopus egg extracts and showed that B-Raf activation is regulated in an M-phase-dependent manner. The mechanism that mediates B-Raf activation at mitosis has not been elucidated. Interestingly, activation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18434602
DOI: 10.1091/mbc.e07-07-0679
PMCID: PMC2441668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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