Kidney Single-cell Transcriptomes Predict Spatial Corticomedullary Gene Expression and Tissue Osmolality Gradients

Abstract excerpt

Background Single-cell transcriptomes from dissociated tissues provide insights into cell types and their gene expression and may harbor additional information on spatial position and the local microenvironment. The kidney’s cells are embedded into a gradient of increasing tissue osmolality from the cortex to the medulla, which may alter their transcriptomes and provide cues for spatial reconstruction. Methods...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chronic Kidney Disease and Diabetes
• Share to Renal and related cancers
• Share to Single-cell and spatial transcriptomics