Article
P.R4810K, a polymorphism of RNF213, the susceptibility gene for moyamoya disease, is associated with blood pressure.
Environmental health and preventive medicine - 1 Mar 2013
Koizumi Akio, Kobayashi Hatasu, Liu Wanyang, Fujii Yukiko, Senevirathna S T M L D, Nanayakkara Shanika, Okuda Hiroko, Hitomi Toshiaki, Harada Kouji H, Takenaka Katsunobu, Watanabe Takao, Shimbo Shinichiro
Abstract excerpt
BACKGROUND: Moyamoya disease-an idiopathic vascular disorder of intracranial arteries-is often accompanied by hypertension. RNF213 has been identified as a susceptibility gene for moyamoya disease. In the present study, the association of p.R4810K (G>A) with blood pressure (BP) was investigated in a Japanese population. METHODOLOGY/PRINCIPAL FINDINGS: Three independent study populations, the Nyukawa (n = 984),...
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