Article
Clec10a regulates mite-induced dermatitis.
Science immunology - 6 Dec 2019
Kanemaru Kazumasa, Noguchi Emiko, Tahara-Hanaoka Satoko, Mizuno Seiya, Tateno Hiroaki, Denda-Nagai Kaori, Irimura Tatsuro, Matsuda Hiroshi, Sugiyama Fumihiro, Takahashi Satoru, Shibuya Kazuko, Shibuya Akira, Fujisawa Yasuhiro, Nakamura Yoshiyuki
Abstract excerpt
House dust mite (HDM) is a major allergen that causes allergic diseases such as atopic dermatitis. However, the regulatory mechanisms of HDM-induced immune responses are incompletely understood. NC/Nga mice are an inbred strain that is more susceptible to HDM and develops more severe dermatitis than other strains. Using whole-exome sequencing, we found that NC/Nga mice carry a stop-gain mutation in Clec10a, which...
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