Article
Differential quantitative proteomics reveals key proteins related to phenotypic changes of breast cancer cells expressing progesterone receptor A.
The Journal of steroid biochemistry and molecular biology - 1 Apr 2020
Pateetin Prangwan, Pisitkun Trairak, McGowan Eileen, Boonyaratanakornkit Viroj
Abstract excerpt
Progesterone receptor isoforms A and B exert different biological effects in breast cancer cells. Alteration of PRA/PRB ratio is often observed during breast cancer progression. High PRA/PRB ratios in breast cancer patients are associated with resistance to chemotherapy and poor prognosis. While it is well accepted that PRA and PRB regulate different sets of genes, how the expression of PRA and PRB alters breast...
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