Dominant mutants of the calcineurin catalytic subunit (CNA-1) showed developmental defects, increased sensitivity to stress conditions, and CNA-1 interacts with CaM and CRZ-1 in Neurospora crassa.

doi:10.1007/s00203-019-01768-z

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Article

Dominant mutants of the calcineurin catalytic subunit (CNA-1) showed developmental defects, increased sensitivity to stress conditions, and CNA-1 interacts with CaM and CRZ-1 in Neurospora crassa.

Archives of microbiology - 1 May 2020

Kumar Ajeet, Roy Avishek, Deshmukh Mandar V, Tamuli Ranjan

Abstract excerpt

We studied a dominant mutant of the Neurospora crassa calcineurin catalytic (cna-1) subunit generated using the repeat-induced point mutation (RIP). The Cna-1RIP mutants showed defects in morphology, aerial hyphae development, carotenoid accumulation, and fertility. The Cna-1RIP mutants also showed sensitivity to osmotic stress and a reduction in acquisition of thermotolerance on exposure to lethal heat shock...

Topics

Calcineurin
Calmodulin
Catalytic Domain
Hyphae
Mutation
Neurospora crassa
Protozoan Proteins
Stress, Physiological

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PMID: 31807806
DOI: 10.1007/s00203-019-01768-z

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